Pre-Pseudarthrosis of Tibia with Presumed Neurofibromatosis
نویسندگان
چکیده
منابع مشابه
Biologic characteristics of fibrous hamartoma from congenital pseudarthrosis of the tibia associated with neurofibromatosis type 1.
BACKGROUND Fibrous hamartoma is a key pathologic component of congenital pseudarthrosis of the tibia, a challenging and disabling bone disorder. We investigated the biologic characteristics of fibrous hamartoma cells in order to better understand the pathogenesis of this rare disease. METHODS Fibrous hamartoma tissues were surgically excised at the time of osteosynthesis from seven patients w...
متن کاملCongenital Pseudarthrosis of the Tibia
Forty cases of congenital pseudarthrosis of the tibia were reviewed. The results were assessed so as to emphasise function rather than simply the presence or absence ofunion. At the time ofreview, 14 patients had undergone amputation; eight others had non-union or tenuous union. No surgical procedure except the Farmer operation (a composite skin and bone pedicle graft from the other leg) showed...
متن کاملDisturbed Osteoblastic Differentiation of Fibrous Hamartoma Cell from Congenital Pseudarthrosis of the Tibia Associated with Neurofibromatosis Type I
BACKGROUND Fibrous hamartoma is the key pathology of congenital pseudarthrosis of the tibia (CPT), which was shown to have low osteogenicity and high osteoclastogenicity. This study further investigated the mechanism of impaired osteoblastic differentiation of fibrous hamartoma cells. METHODS Fibroblast-like cells were obtained from enzymatically dissociated fibrous hamartomas of 11 patients ...
متن کاملPseudarthrosis of the Tibia in Childhood5
The purpose of this paper is to report the late results of treatment by the use of the “by-pass “graft, to give a brief account of all the patients treated, and to discuss the possible causes of inception and maintenance of the condition. It is now fourteen years since the by-pass graft was first introduced. It was used for two patients in the same year and both cases were described in my origi...
متن کاملFemoral overgrowth in children with congenital pseudarthrosis of the Tibia
BACKGROUND Having observed a tendency towards femoral overgrowth (FO) of the affected limb in children with atrophic-type congenital pseudarthrosis of the tibia (CPT), we aimed to identify the incidence of, contributors to, and patterns of FO among such children. METHODS We retrospectively evaluated 55 children with CPT, 22 with prepseudarthrosis and 33 with atrophic-type CPT from 1989 to 201...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1951
ISSN: 0035-9157
DOI: 10.1177/003591575104400325